NK cell antitumor function is inhibited by TGF-β-mediated downregulation of the expression of NK-activating receptors NKp30 and NKG2D and also reduces the expression of NKG2D ligands on tumor cells, thus suppressing NK-mediated cytotoxic capacity and IFN-γ secretion (103). The gene discussed is IFNG; the disease is neoplasm.