Currently, the safety and efficacy of anti-TIGIT Ab, alone or in combination with anti-PD-1 or anti-PD-L1 Abs, are being evaluated in phase I and II clinical trials in patients with locally advanced or metastatic solid tumors, e.g., renal cell carcinoma, non-small cell lung cancer, breast cancer, squamous cell carcinoma of the head and neck, melanoma, and colorectal cancer (NCT03119428, NCT03563716, NCT03628677). This evidence concerns the gene PDCD1 and melanoma.