As a proof of concept, the analysis of the TLR9 down-stream genes’ activation (Huang and Yang, 2010), in the presence of mRNA sensor molecules (TLR3, TLR7, TLR8) antagonists/inhibitors, showed that HHV-6B and HHV-7 infections induced an increase in TNF-alpha and IL-8 expression, with the highest levels reached by IL-8 during HHV-7 infection. Here, TLR9 is linked to HHV-7 infectious disease.