Nav1.5 (encoded by SCN5A) is the major regulator of cardiac excitation and mutations in Nav1.5 are associated with a number inherited arrhythmogenic channelopathies and disorders including Brugada syndrome, long QT syndrome, and atrial fibrillation (Abriel, 2007; Detta et al., 2015). Here, SCN5A is linked to channelopathy.