Ankyrin-G is required for proper targeting of Nav1.5 to the cardiomyocyte intercalated disc and loss of ankyrin-G results in lethal dilated cardiomyopathy, bradycardia, and hypersensitivity to cardiac arrhythmia (Makara et al., 2014, 2018). The gene discussed is SCN5A; the disease is chronic obstructive pulmonary disease.