CNR1 and infection: A role for CB1R in endothelial cells has also been described, as AEA administration inhibits the induction of VCAM-1 in endothelial cells after TMEV infection and decreases leukocyte transmigration in an in vitro model of the BBB, an effect that is absent in the presence of CB1R selective antagonists (Mestre et al., 2011).