Recently, we have revealed that both CUL4A and CUL4B associate with RBX1, DDB1, and DCAF4 to assemble two separate CRL4DCAF4 E3 complexes, whose activation causes the hyper-ubiquitination and degradation of ST7 (suppression of tumorigenicity 7), eventually leading to the pathogenesis of CRC 14. The gene discussed is CUL4B; the disease is colorectal carcinoma.