CTBP1 and neoplasm: Overexpression of CtBP1 can downregulate multiple tumor suppressors, such as BRCA1 (Breast cancer susceptibility gene 1), CDH1 (Cadherin 1), Bax (BCL2-associated X), Bim (Bcl-2 interacting mediator of cell death), and PTEN (phosphatase and tensin homolog) 32.