A dose-dependent association between the cumulative amount of alcohol consumption over time and HCC risk in individuals with the ALDH2*1/*2 or ALDH2*2/*2 genotype was reported based on a comparison of a HCC cohort of 208 cases and a control cohort of 208 control cases conducted in Jiangsu, China 55. This evidence concerns the gene ALDH2 and hepatocellular carcinoma.