ALDH18A1 and cancer: Furthermore, the overexpression of ALDHs (mainly ALDH1, ALDH3A1, and ALDH18A1) confers cancer cells with a survival advantage because oxidative stress resulting from high metabolic activity leads to ROS generation, lipid peroxidation, and the accumulation of toxic aldehydes, which can inhibit the proliferation and survival of cancer cells 97.