However, the correlation of the ALDH2*1/*1 genotype with increased HCC risk in HBV-positive patients with cirrhosis was suggested based on an analysis of 4155 HBsAg-seropositive participants, but no causal relationship was found between the ALDH2*1/*2 or ALDH2*2/*2 versus the ALDH2*1/*1 when alcohol drinking habits were considered 91. Here, ALDH2 is linked to hepatocellular carcinoma.