As reported, ALDH1B1 activity was downregulated in liver cancer tissues compared to normal liver tissue, and the reduced ALDH1B1 activity was considered protective in HCC patients through its influence on the oxidation of short-chain aldehydes including acetaldehyde and propionaldehyde 16, and its protective against alcohol-induced hepatocellular proliferation and hepatic neoplasm in mice 99. This evidence concerns the gene ALDH1B1 and hepatocellular carcinoma.