CTNNB1 and hepatocellular carcinoma: ALDH3A1 was reported to be significantly upregulated in HCC and adenoma, resulting in the activation of the Wnt/β-catenin pathway and CTNNB1 mutations, and ALDH3 may slow the growth of HCC cells and inhibit the formation of aldehydes derived from lipid peroxidation 102, 103.