In this study, we provide evidence of neuroimmune signaling persistently increasing DR signaling in AUD hippocampus through TL1A-DR3 and FasL–Fas, FADD and TRADD, and caspases-3, -7, -8, and -9 that likely contribute to apoptotic and other forms of AUD neurodegeneration that may be shared by other brain diseases associated with increased neuroimmune gene expression. Here, TNFRSF25 is linked to brain disorder.