CASP3 and brain disorder: In this study, we provide evidence of neuroimmune signaling persistently increasing DR signaling in AUD hippocampus through TL1A-DR3 and FasL–Fas, FADD and TRADD, and caspases-3, -7, -8, and -9 that likely contribute to apoptotic and other forms of AUD neurodegeneration that may be shared by other brain diseases associated with increased neuroimmune gene expression.