Interestingly, in contrast to the temporal and spatial pattern of the α-synuclein distribution associated with the ascending Braak scheme in PD, the SNCA expression signature across brain regions R1–R6 in non-neurological brains followed a reverse pattern with lowest expression in preclinically involved regions (brainstem) and highest expression in clinically involved regions (limbic system and cortex). The gene discussed is SNCA; the disease is Parkinson disease.