From Fig. 1B we observed a path from CREBBP to AD and T2DM via gene connections: \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$CREBBP\to CBL\to MAP2K4\to MAPK8\to MAPK1\to PIK3CA$$\end{document}CREBBP→CBL→MAP2K4→MAPK8→MAPK1→PIK3CA. The gene discussed is PIK3CA; the disease is type 2 diabetes mellitus.