The number of expression genes that were directly connected to both AD and T2DM was two genes: GRMD1B, RP1-111D6.3, the number of expression genes that were directly connected to AD, but not directly connected to T2DM was 19 (P-value < 10−4, Table S4) and the number of expression genes that were directly connected to T2DM, but not directly connected to AD was 7 (P-value < 10−4, Table S5). Here, RP1 is linked to Alzheimer disease.