MAPT and Alzheimer disease: Alzheimer’s dementia with great economic, political and social consequences is a progressive, irreversible degenerative disease of the brain and is the most common cause of dementia due to the gradual accumulation of amyloid-beta \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$(A\beta )$$\end{document}(Aβ) and twisting of tau protein1,2, and other common brain pathologies3.