Interestingly, Gal-3 knock-out mice displayed significantly decreased liver fibrosis with reduced expression of Tgfβ1, Acta2 and Col1a1 vs. WT following bile duct-ligated to induce experimental live fibrosis, suggesting that Gal-3 also played important roles in liver fibrosis16. This evidence concerns the gene LGALS3 and Hepatic fibrosis.