TGFB1 and Hepatic fibrosis: In this study, to shed light on the mechanism underlying the progression of liver fibrosis caused by P.g.-odontogenic infection, the roles of HSC activation caused by P.g.- infection through gingipain and P.g.-derived LPS/lipoprotein stimulations in the process of liver fibrosis have been analyzed, especially focusing on TGF-β1 and Gal-3.