Several signaling pathways and molecules for hepatic fibrosis have been identified including TGF-β1/Smad and /ERK signaling pathways as the major pathways for the activation of HSC that lead to up-regulation of the markers of liver fibrosis such as a-smooth muscle actin (α-SMA) and type I collagen14,16–19. Here, TGFB1 is linked to Hepatic fibrosis.