CYCS and cancer: MRS2 is a magnesium transporter in the mitochondrial inner membrane, but the literature does offer clues as to why it might be a highly connected gene in the transcriptomic network: a knock-down in vitro study indicated that it acted to shift mitochondrial energy metabolism and was critical for cellular response to stress24; additionally, it was associated with cytochrome C release25 in gastric cancer cells, and therefore its connection to other mitochondrial genes and importance in cancer seems plausible.