In our previous work, we have investigated the expression levels of RUNX2 in 124 CRC tumor specimens, and the results demonstrated that RUNX2 mRNA levels were significantly higher in primary tumors and in metastatic sites than in nonmetastatic tumors, and its mRNA levels were inversely correlated with CRC TNM stages, and liver and lung metastasis23. The gene discussed is RUNX2; the disease is colorectal carcinoma.