ITGBL1 and neoplasm: Similar to fibroblasts educated by ITGBL1-enriched EVs, primary CAFs with high ITGBL1 expression promoted tumorigenicity (Supplementary Fig. 17e, f), tumor stemness (Supplementary Fig. 17g), metastatic growth (Supplementary Fig. 17h, i), and EMT (Supplementary Fig. 17j).