The results demonstrated that CRC patients with lower ITGBL1 mRNA-expressing tumors had improved prognosis (Fig. 1d, e), and the mRNA levels of ITGBL1 were closely associated with CRC TNM (tumor, lymph node, and metastasis) stages, and liver and lung metastasis (Supplementary Table 1). This evidence concerns the gene ITGBL1 and neoplasm.