In addition to ITGBL1, several other integrins, including ITGα6, ITGβ4, and ITGβ1 were also packed in the plasma EVs of CRC patients with lung metastases, whereas ITGα5 and ITGβ5 were found in liver metastases (Supplementary Fig. 3b–f). Here, ITGB1 is linked to colorectal carcinoma.