Notably, CRC-ITGBL1-enriched EVs increased the frequency of α-SMA + hStCs, myofibroblasts, FN deposition, and recruitments of F4/80+ macrophage, and Ly6G+ myeloid cells to the liver (Fig. 3e, Supplementary Fig. 5b–e) or lung (Fig. 3f, Supplementary Fig. 5f–i). This evidence concerns the gene FN1 and colorectal carcinoma.