Consistent with previous reports in the literature27–29,44,45 we find that p-AKT and p-ERK1/2 are more strongly activated in tumor-associated blood vessels than in the surrounding tumor tissue, although longer-exposure images confirm that p-AKT and p-ERK1/2 are indeed also present in the surrounding tumor cells (Supplementary Fig. 14M, N). The gene discussed is MAPK3; the disease is neoplasm.