In order to show that the effects on tumor growth are due to targeting of the tumor-associated host endothelium rather than the tumor cells themselves, we generated inducible EC-specific Cds2 knockout (ECKO) mice by crossing the Cad5(PAC)-CreERT2 EC specific Cre line42 to Cds2tm1a(KOMP)Wtsi (i.e. Cds2lox/lox) mice43. The gene discussed is CDS2; the disease is neoplasm.