CDS2 and neoplasm: To determine whether systemic inhibition of PI recycling still preferentially reduces signaling in tumor-associated ECs as compared to quiescent endogenous ECs in this model of pre-exisiting tumors, we analyzed ECs from lungs (Supplementary Fig. 15A–E) or tumors (Supplementary Fig. 15F–J) of the same Cds2 vMO treated, LLC-allografted mice via Western blot analysis.