N-DhiPSC are more effectively reprogrammed from a donor’s skin or blood cells back to a pre-diseased state, and could subsequently be differentiated to unlimited quantities of pristine, transplantable N-DVP. Unlike adult diabetic EPC, N-DVP generated from tankyrase/PARP inhibitor-regulated N-DhiPSC would be unaffected by the functional and epigenetic damage caused by chronic hyperglycemia. This evidence concerns the gene TNKS and Hyperglycemia.