Consistent with its broad expression in lungs, including bronchial epithelial cells, alveolar macrophages and pulmonary vasculature11–13, TRPC6 contributes to pulmonary disorders, such as cystic fibrosis, asthma, pulmonary hypertension, COPD, lung edema, and lung fibrosis11,14,15. Here, TRPC6 is linked to chronic obstructive pulmonary disease.