For example, adoptive transfer of Id3−/− T cells in mice is sufficient to induce symptoms of SS, but neonatal (3-day) thymectomy in Id3−/− mice reduced these symptoms20 Moreover, conditional knockout mice with a specific deletion of Id3 only in T cells show a similar SS phenotype as systemic Id3−/− mice do21. This evidence concerns the gene ID3 and synovial sarcoma.