In addition, our results showed that ASV/lncRNA sirt1 AS/sirt1/Akt/foxo3 signaling pathway participates in modulating TGE-β1 induced EMT and thus alleviated BLM-induced pulmonary fibrosis, providing a novel molecular basis for the application of ASV in the therapy of IPF. This evidence concerns the gene FOXO3 and idiopathic pulmonary fibrosis.