Having established that human TB lungs show increased CSE and MPST levels (Fig. 1 and SI Appendix, Figs. S1–S5), and that infected WT macrophages produce supraphysiological levels of H2S (Fig. 4 F–J), it is reasonable to hypothesize that excessive levels of H2S impairs bioenergetic homeostasis of the infected cell to exacerbate disease. The gene discussed is MPST; the disease is tuberculosis.