AKT1 and asthma: Studies have shown that abnormalities in multiple signaling pathways in lung tissue involve the development and progression of asthma, such as PI3K/Akt, MAPK, ERK, JAK and c-Jun (El-Hashim et al., 2017; Li et al., 2015; Southworth et al., 2018; Wagh et al., 2017; Yang et al., 2018).