CDO1 and neoplasm: On the other hand, in the subgroup with tumor size 0–1 cm, the gene panel CDO1, TAC1, and SOX17 (sensitivity 71%, specificity 82%, and AUC 0.81, respectively) was slightly better than gene panel CDO1, SOX17, and HOXA7 (64%, 82%, and 0.75, respectively), indicating this panel may have better sensitivity and diagnostic accuracy in the detection of very small lung cancer lesions (Tables 5, 6 and 7).