Building upon this research, we recently documented corticostriatal global DNA methylome deficits in first- and second-generation adolescent DNE mice that co-occur with the multigenerational transmission of neurodevelopmental disorder-like behavioral perturbations, nAChR and DAT dysfunction, proBDNF/BDNF imbalance, furin deficits, and atypical glucocorticoid receptor activity [39, 40]. Here, FURIN is linked to neurodevelopmental disorder.