Congruent with the putative role of DNMT3A downregulation in neurodevelopmental disorder-associated and DNE-evoked DNA methylome deficits, contemporary rodent research demonstrates deregulation of TET2, an enzyme which catalyzes DNA demethylation, accompanied by global DNA hypomethylation in peripheral tissues of first-generation DNE offspring [72]. Here, TET2 is linked to neurodevelopmental disorder.