Toward an improved understanding of the epigenetic mechanisms underlying the association of DNE with neurodevelopmental disorders in children and grandchildren, the present study addresses a void in the literature concerning the hitherto unknown multigenerational impacts of DNE on DNMT3A, TET2, MeCP2, and HDAC2 expression as well as MeCP2 (Ser421) and HDAC2 (Ser394) phosphorylation in the adolescent frontal cortices, striata, and hippocampi. Here, HDAC2 is linked to neurodevelopmental disorder.