In support of this inference, alterations in corticostriatal and hippocampal DNMT3A and TET2 expression perturb the DNA methylome and thereby disrupt neurodevelopment, neuroplasticity, and synaptogenesis, elicit neurodegeneration, impair learning, memory, and cognition, and modify anxiety, stress responsivity, and emotional behaviors, and this cascade of DNMT3A and TET2 downregulation-induced DNA methylome perturbation occurs in neurodevelopmentally disordered and DNE children as well as animal models thereof [1, 35, 37, 38, 59, 67, 75–98]. This evidence concerns the gene DNMT3A and Anxiety.