Of further relevance to neurodevelopmental disorders and the multigenerational impacts of DNE, MeCP2 (Ser421) phosphorylation regulates neurodevelopment and neuronal function, experience-dependent chromatin remodeling, dendritic outgrowth and spine maturation, BDNF expression, and the neural circuitry of behavior [118–120]. Here, MECP2 is linked to neurodevelopmental disorder.