Given that neurodevelopmental disorders and DNE are associated with dysfunction of DNMT3A, TET2, MeCP2, and HDAC2, we posited that dysregulation of these proteins may contribute to the increased risk of neurodevelopmental disorders in DNE children and grandchildren as well as the neurodevelopmental disorder-like phenotypes exhibited by rodent DNE offspring and grandoffspring. The gene discussed is HDAC2; the disease is neurodevelopmental disorder.