In support and expansion of previous epidemiological and animal model research, we recently reported that DNE precipitates multigenerational neurodevelopmental disorder-like hyperactivity, risk-taking behaviors and circadian disruptions as well as neurobiological perturbations in the frontal cortex and striatum including nicotinic acetylcholine receptor (nAChR) and DA transporter (DAT) dysfunction, proBDNF–BDNF imbalance, furin downregulation, and glucocorticoid receptor hypoactivity accompanied by hypocorticosteronemia [20–40]. Here, CHRNA4 is linked to neurodevelopmental disorder.