CHRNA4 and neurodevelopmental disorder: Possible explanations for the regioselectivity of intergenerational DNE-evoked HDAC2 downregulation again include variable nAChR expression patterns and/or subunit compositions across the brain regions assessed, which could differentially contribute to the neurodevelopmental disorder-like neurobehavioral anomalies exhibited by first- and second-generation DNE mice [39, 40].