In addition to the putative roles of perturbed MeCP2 and HDAC2 expression in neurodevelopmental disorders, aberrant posttranslational modifications of MeCP2 and HDAC2 may alter the function of these epigenetic factors and thereby further contribute to neurodevelopmental disorders as well as the multigenerational impacts of DNE. Here, MECP2 is linked to neurodevelopmental disorder.