Furthermore, MALAT1 silencing presented with larger brain infarct size, worse neurological scores, and reduced sensorimotor functions post-MCAO [20].In the present study, we demonstrated that inhibition of MALAT1 had a protective effect against cerebral ischemia/reperfusion injury by regulating miR-145/AQP4 expression. Here, AQP4 is linked to brain ischemia.