AQP4 and Cerebral ischemia: To explore the underlying mechanism of MALAT1 regulating AQP4 in cerebral ischemia-reperfusion injury, we used starBase (http://starbase.sysu.edu.cn/) to screen miRNAs that have complementary base pairing with MALAT1. Interestingly, miR-145 was identified as a potential target of MALAT1 (Fig. 3a).