As shown in Fig. 6 a-c, the mRNA and protein expression of EGR3 were significantly lower in liver tissues of the Cirrhosis group than in tissues of the Control group (P < 0.05), and were significantly lower in liver tissues of the Liver cancer group than in tissues of the Cirrhosis group (P < 0.05). This evidence concerns the gene EGR3 and Cirrhosis.