Due to the fact that B7-H6 belongs to a family composed of both co-stimulatory and co-inhibitory receptors [14], it follows that the supposition has arisen that this ligand for NKp30 also may play a role in the biology of the tumor cells themselves, perhaps promoting tumor cell survival, proliferation, migration and invasion [9, 15, 16]. Here, NCR3LG1 is linked to neoplasm.