We herein provide evidence that liraglutide could rescue tau hyperphosphorylation and the formation of Aβ plaque deposition which occurred under hyperinsulinemic and insulin-resistant conditions by resensitization of a neuronal insulin signaling as well as halting of overactivity of BACE-1, suggesting that liraglutide might exert a beneficial effect for AD subjects with an insulin-resistant condition. This evidence concerns the gene MAPT and Alzheimer disease.