CCN2 and cancer: The c-Myc oncogenic transcription factor (MYC) transactivates expression of the miR-17~92 cluster (also known as oncomiR-1), and MYC-activated miR-17~92 promotes cancer progression by controlling expressions of E2F1, connective tissue growth factor (CTGF), thrombospondin 1 (THBS1), and phosphatase and tensin homolog (PTEN) in multiple cancers [39,40,41,42,43,77].