Since it has been reported that the NR superfamily contains 48 human members, including the hormone receptors: estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), glucocorticoid receptor (GR), and mineralocorticoid receptor (MR) [78], several studies have shown that NRs, especially ER and AR, not only indirectly change miRNA abundance through diverse signaling pathways but also directly regulate the transcriptional activity of miRNAs in cancer. Here, ESR1 is linked to cancer.