The impression that the NLRP3 inflammasome is not activated by hypervolemia is strengthened by data showing that the mRNA level of IL-18, a cytokine which is also regulated by the NLRP3 complex, is not different in H-HD and N-HD patients (H: 1.3 ± 0.6 vs. H: 1.1 ± 0.4, p = 0.222, Figure 3c). The gene discussed is NLRP3; the disease is Huntington disease.