TP53 and cancer: The majority of p53 mutations are missense mutations (i.e., R175H, R248Q, and R273H) that are mainly within the DNA-binding domain (DBD), leading to the synthesis of p53 proteins that are unable to bind target gene promoters; however, some mutant (mut) p53 proteins can physically bind other transcription factors, profoundly remodeling the cancer cell transcriptome and proteome [2].