For instance, the downregulation of mutp53 interferes with the downstream activation of the cross-talk between NRF2 and p62, restoring the cytotoxic effect of chemotherapies [49], and mutp53 inhibits the pro-apoptotic and pro-survival UPR effectors PERK and ATF6 in cancer cell lines [50], suggesting that UPR inhibitors combined with mutp53 inhibitors may increase cell death. The gene discussed is EIF2AK3; the disease is cancer.