The IRE1α signaling pathway induces the expression of the transcription factor Xbp1s, which increases the expression of ER chaperones and ER mass, stimulates lipid biogenesis, and degrades unfolded proteins to enhance the secretory function of ER and triggers autophagy initiation, mainly serving as a pro-survival pathway in multiple human cancers [35]. The gene discussed is ERN1; the disease is cancer.