Inflammation-related miRNAs including miRNA let-7a, let-7b, miR-27a, miR-146a, miR-451, miR-223, miR-142-5p, miR-532-3p and miR-155 were significantly upregulated in peripheral monocytes from SOD1 mice and ALS patients with familial and sporadic disease. Here, SOD1 is linked to amyotrophic lateral sclerosis.