In tumor-associated endothelial cell VEGF can modulate adhesion molecules expression, such as vascular cell adhesion molecule-1 (VCAM1) and intercellular adhesion molecule-1 (ICAM1), and chemokines expression, ultimately promotes the creation of a specific barrier that serves as an impermeable block to certain immune cells [66,67,68]. Here, ICAM1 is linked to neoplasm.