SNCA and Parkinson disease: The discovery of seven missense mutations, A53T, A30P, E46K, H50Q, G51D, A53V and A53E [6,71,72,73,74,75,76,77], as well as duplication and triplication [78,79] of the SNCA gene encoding for α-syn as a cause of several PD familial cases undoubtedly rises the interest of the field towards SNCA gene targeting.