NOTCH1 and glioblastoma: Zheng et al. [85], studying the knockdown of EZH2 in GBM cells, observed a significant downregulation of Notch1, a transmembrane protein with an important role in cell embryonic and postnatal development [85,86,87,88] that is overexpressed in many cancer types, like breast, lung, pancreatic, and colon cancer [88].