Furthermore, many studies have revealed that Gal-3 expression is detected in many disease conditions, such as heart disease [17,18,19,20,21,22,23], kidney disease [24,25,26,27], diabetes mellitus [24,25,28], viral infection [29,30,31,32], autoimmune disease [33,34,35,36], neurodegenerative disorders [37,38,39,40,41,42], and tumor formation [43,44,45,46,47,48,49,50,51,52]. Here, LGALS3 is linked to autoimmune disease.