MTOR and cholangiocarcinoma: Janpipatkul et al., demonstrated that KKU-M213 cells (CCA cells derived from Thai patients with iCCA) treated with 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid had a reduction in L-leucine uptake that consequently inhibits mTOR pathway activity and therefore reduces cell proliferation and viability.