Also Xu L., et al., pointed out a central role of PDK regulation in CCA: in this manuscript the authors demonstrated that in CCA the decrease of SIRT3 expression induced the glycolytic flux through the hypoxia inducible factor α (HIF1α)/PDK1/pyruvate dehydrogenase (PDHA1) axis, promoting tumor progression. Here, SIRT3 is linked to cholangiocarcinoma.