Notably, mitochondrial signatures, including adenosine triphosphate 5A (ATP5A), nicotinamide adenine dinucleotide reduced form (NADH):ubiquinone oxidoreductase subunit S3 (NDUFS3), and succinate dehydrogenase complex iron sulfur subunit B (SDHB), were identified in purified sEVs from older adults with PD. The gene discussed is SDHB; the disease is Parkinson disease.