The KU812 and KU812R RT-qPCR results are shown in Figure 5B. A significant increase in the mRNA expression level of Nrf2, Trx1 and TrxR1 and a significant decrease in the mRNA expression levels of TXNIP were observed, consistent with an overall upregulation of the Trx system in the imatinib resistant CML cells compared to the parental cell lines. This evidence concerns the gene TXNIP and chronic myelogenous leukemia, BCR-ABL1 positive.