ASAH1 is required during the 2‐4 cell blastomere stage during embryonic development but is largely dispensable in somatic cells as demonstrated by nearly phenotype‐free conditional knockout mice.4, 5 The requirement for ASAH1 during early embryonic development is intriguing as the blastomere stage is hypothesized to hold a key in the process of cancer resistance and recurrence.6, 7. This evidence concerns the gene ASAH1 and cancer.