Acid ceramidase (ASAH1) hydrolyzes the pro‐death sphingolipid ceramide and plays a critical role in driving recurrence in prostate cancer and in supporting tumor‐initiating cells in glioblastoma and melanoma.1, 2, 3 While ASAH1 appears to be crucial in subpopulations of cells that seed tumors, the underlying reason is not fully elucidated. The gene discussed is ASAH1; the disease is glioblastoma.