MetS was defined when 3 or more of the following were satisfied: hypertriglyceridemia (≥150 mg/dL) or taking lipid-lowering drugs; elevated BP (≥85 mm Hg diastolic, ≥130 mm Hg systolic) or taking antihypertensive drugs; low high-density lipoprotein cholesterol (<50 mg/dL in women,<40 mg/dL in men); hyperglycemia (fasting glucose ≥100 mg/dL) or taking hypoglycemic agents drugs or insulin; and increased waist circumference (≥88 cm for women, ≥102 cm for men). The gene discussed is INS; the disease is metabolic syndrome.