Ten samples of these ameloblastoma cases were investigated for immunohistochemical staining of PTEN. We found loss of PTEN expression in 3 of 5 (60%) ameloblastoma samples with PTEN promoter methylation while PTEN expression was present in 4 of 5 (80%) ameloblastoma samples with no PTEN promoter methylation (Table 1). The gene discussed is PTEN; the disease is ameloblastoma.