HK2 and cancer: In line with ample evidence for the involvement of aerobic glycolysis in cancer cell energy metabolism [34, 35], B16F10 and YUMM1.7 cells exhibit high baseline glycolytic gene expression with strong upregulation by hypoxia, especially of genes encoding the glycolytic pathway‐controlling proteins, glucose transporter 1, which facilitates glucose uptake [36] and hexokinase 2 that catalyzes the first and rate limiting step of glycolysis [37].