Previous studies have shown that sclerostin antibodies can be used to treat osteoporosis and skeletal abnormalities, increasing bone formation, bone mass and bone strength.18, 19, 20, 21, 22, 41, 42, 43 Additionally, sclerostin antibodies have been reported to promote fracture callus formation and increase the stability of internal fixation.44 However, studies addressing the role of sclerostin in osteolysis of prosthesis are still lacking. Here, SOST is linked to osteoporosis.