Some studies have shown that SOST gene and sclerostin are associated with sclerosis, fracture healing and osteoporosis.18, 19, 20, 21 Bone volume of osteoporosis is increased, and implant fixation is improved after SOST/sclerostin blockage.22 However, it is still unclear whether SOST/sclerostin is involved in periprosthetic osteolysis and whether reduction of SOST gene is effective in delaying osteolysis caused by wear particles. Here, SOST is linked to osteoporosis.