STX6 and progressive supranuclear palsy: Of note, mode-cluster 36 was also strongly associated with other SNPs, amongst them one (rs1044595) in an exon of STX6, and in high LD with a SNP associated with tauopathy progressive supranuclear palsy (Höglinger et al., 2011), and correlated in the UK Biobank participants with hormonal replacement treatment.