Induction of FST expression by FLT3/ITD could be recapitulated in adult FLT3/ITD‐transgenic zebrafish, Flt3/ITD knock‐in mice, and human FLT3/ITD primary AML‐derived murine xenografts, which was mediated by CREB phosphorylation. Here, FLT3 is linked to acute myeloid leukemia.