Upregulation of RET, IL2RA, and CCL5 was confirmed by RT–qPCR (Fig 4J), of which IL2RA and CCL5 were shown to highly express in human AML compared with normal hematopoietic tissues (Appendix Fig S4) and were associated with poor overall survival in AML patients (Fig 4K and L). This evidence concerns the gene IL2RA and acute myeloid leukemia.