For example, the ability to disentangle highly correlated measured adipokine levels from each other and from other metabolic perturbations associated with the obese phenotype (e.g. insulin resistance, chronic inflammation) may be limited when using conventional multivariable regression methods.35 Additionally, it is possible that previously reported associations of inflammatory markers like CRP with breast cancer could represent the effect of early stage or latent breast cancer on subsequent inflammation levels.36 This evidence concerns the gene CRP and breast cancer.