Immunoglobulin E (IgE) plays a central role in allergic disease through the interaction between its Fc region (IgE-Fc) and the Fc∊RI receptor, in which cross-linking of Fc∊RI-bound IgE by allergen triggers mast cell and basophil degranulation, with the release of inflammatory mediators (Gould & Sutton, 2008 ▸). This evidence concerns the gene IGHE and allergic disease.