We also recommend that preclinical research should adopt a wide variety of models (Van Damme et al., 2017; Lutz, 2018), particularly of mutations accounting for the commoner causes of ALS, such as the C9orf72 repeat expansion (DeJesus-Hernandez et al., 2011; Renton et al., 2011). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.