CHCHD10 and amyotrophic lateral sclerosis: Finally, not only are there a plethora of ALS-causing mutations that have been identified that impact on mitochondrial function (Smith et al., 2017), there is also direct evidence that disruption of mitochondrial structure and function contributes to the aetiology of ALS, owing to the discovery of causative mutations in the gene encoding the mitochondrial protein, CHCHD10, which is localized to contact sites between the inner and outer mitochondrial membrane (Bannwarth et al., 2014).