SOD1 and amyotrophic lateral sclerosis: Thus, SOD1 transgenic models are likely to recapitulate only certain aspects of ALS (Joyce et al., 2011); notwithstanding this, there is emerging evidence that misfolded SOD1 protein is pathologically present in sporadic ALS with no known genetic cause (Paré et al., 2018), and in cases of ALS caused by mutations in known ALS genes other than SOD1 (Forsberg et al., 2019), suggesting that SOD1 biology may well be involved in ALS pathogenesis in general.