The recruited ATMs secrete both anti-inflammatory (interleukin-10 (IL-10) and IL-1) and pro-inflammatory (tumor necrosis factor-α (TNF-α), IL-6, and IL-1β) cytokines, suggesting they can serve both a protective and harmful role in obesity [114]. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.