GPT and diabetes mellitus: For that reason, elevated activities of SGOT and SGPT in the plasma might be due mostly to the escape of these enzymes from the liver cell cytosol into the bloodstream, which is a signal of the hepatotoxic effect of STZ.31 Treatment of the diabetic rats with the extract of WGM conditions reduced the activities of these enzymes in plasma compared to those in the gravity and diabetic control groups and consequently alleviated liver damage caused by STZ-induced diabetes, as presented in our results.