PRRT2 and Hyperglycemia: Metabolic alterations such as hyperglycemia, insulin resistance and increased free fatty acid levels, result in the oxidative stress, organelle dysfunction, inflammation, advanced glycation end products (AGEs) formation, activation of protein kinase C (PKC), abnormalities in ion homeostasis, alterations in structural proteins, apoptosis and fibrosis, changes that eventually result in diabetes-induced cardiac dysfunction (Figure 1) (28, 29).